The Chris Isaak Show is a television sitcom which follows a fictionalized version of the life of American rock musician Chris Isaak. The show portrays Isaak and his band members as everyday people with everyday problems. The series was produced for the Showtime channel from 2001–2004, and was filmed in Vancouver, Canada, which stands in for the show’s home setting of San Francisco.

The series featured Isaak and several members of his band, Silvertone, portraying themselves. Other roles were portrayed by actors, including Jed Rees as Isaak’s keyboardist. Rees was hired in place of Isaak’s actual keyboardist Brett Tuggle to add some comedy to the show. Other characters featured on the show include Yola Gaylen, Isaak’s manager and her colleague, Cody Kurtzman. The final regular character, Mona, appears as a mermaid-of-sorts who lies nude on a revolving circular bed in the basement of Bimbo’s, a club Isaak frequents. She typically talks only with Isaak, acting as his conscience or a sounding board for him.