Conner Kent and Krypto escape from Cadmus Labs. His search for the truth about his past leads him to Lionel Luthor and genetic scientist Dr. Eve Watson.

The town of Defiance is shocked when the remains of a leading businessman who went missing almost six years ago, are discovered hidden in the walls of the NeedWant.

Nolan and Irisa arrive in Defiance, where the town is soon divided over the death of Luke McCawley. But a bigger threat forces everyone together: An attack by the Volge.